Abstract |
Avian influenza viruses possess hemagglutinin (HA) which preferentially bind to the sialic acid α2,3-galactose sialyloligosaccharides (SAα2,3Gal) receptor. In contrast, human influenza viruses bind to sialic acid α2,6-galactose sialyloligosaccharides (SAα2,6Gal). The A/Hong Kong/68 (H3N2) virus preferentially binds to SAα2,6Gal, although its HA gene was derived from an avian influenza virus strain. To elucidate the mechanisms behind acquisition of binding specificity for the human-type receptor, the avian influenza virus, A/duck/Hokkaido/5/77 (H3N2), which carries the HA with SAα2,3Gal receptor specificity, was consecutively passaged in pigs. Viruses that preferentially bind to the SAα2,6Gal receptor were predominantly recovered from the nasal swabs of pigs after three passages. The present results indicate that avian influenza viruses can acquire the potential to infect humans after multiple infections in a pig population. Intensive surveillance of swine influenza is, thus, important for the preparedness for the future pandemics.
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Authors | Shintaro Shichinohe, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida |
Journal | Virology
(Virology)
Vol. 444
Issue 1-2
Pg. 404-8
(Sep 2013)
ISSN: 1096-0341 [Electronic] United States |
PMID | 23891155
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Receptors, Virus
- Sialic Acids
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Topics |
- Adaptation, Biological
- Animals
- Ducks
- Influenza A Virus, H3N2 Subtype
(growth & development, isolation & purification, physiology)
- Influenza in Birds
(virology)
- Nasal Cavity
(virology)
- Receptors, Virus
(metabolism)
- Serial Passage
- Sialic Acids
(metabolism)
- Swine
- Virus Attachment
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