[The value of magnesium pyrrolidone carboxylate in true cervix dystocia. A double blind versus placebo study].

The efficacy of spasmolytics in cervix dystocia during labor is very contested. For this reason the authors studied the action of pyrrolidone carboxylate of magnesium for this indication in a double-blind versus placebo study (48 patients divided in two groups). Strict inclusion criteria and homogeneity of the two groups of patients allowed them to find out that the use of this particular magnesium salt reduced significantly the length of labor. Consequently the authors assess that spasmolytics work not only through their placebo effect, which is thought by some authors.
AuthorsJ E Demory, J M Firmin, P Parot
JournalRevue française de gynécologie et d'obstétrique (Rev Fr Gynecol Obstet) Vol. 85 Issue 6 Pg. 413-6 (Jun 1990) ISSN: 0035-290X [Print] FRANCE
Vernacular TitleIntérêt du pyrrolidone carboxylate de magnésium dans les dystocies cervicales pures. Etude en double aveugle contre placebo.
PMID2389112 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Parasympatholytics
  • Placebos
  • Pyrrolidinones
  • Magnesium
  • Pyrrolidonecarboxylic Acid
  • Adult
  • Cervix Uteri (drug effects, physiopathology)
  • Double-Blind Method
  • Drug Tolerance
  • Dystocia (drug therapy)
  • Female
  • Humans
  • Labor, Obstetric (drug effects)
  • Magnesium (therapeutic use)
  • Muscle Relaxation
  • Parasympatholytics (therapeutic use)
  • Placebos
  • Pregnancy
  • Pyrrolidinones (therapeutic use)
  • Pyrrolidonecarboxylic Acid (therapeutic use)
  • Random Allocation

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