Abstract |
The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells following antigen stimulation in vitro tended to have a more prolonged period of high fevers and a longer duration of illness. Thus, an increase of EV71 epitope-specific Th2 type response may portend the poor prognosis for some HFMD patients.
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Authors | Ruicheng Wei, Lijuan Xu, Na Zhang, Kai Zhu, Juhao Yang, Chunhui Yang, Chaoyang Deng, Zhaomin Zhu, Anne S De Groot, Ralf Altmeyer, Mei Zeng, Qibin Leng |
Journal | Virus research
(Virus Res)
Vol. 177
Issue 1
Pg. 62-5
(Oct 2013)
ISSN: 1872-7492 [Electronic] Netherlands |
PMID | 23886670
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Case-Control Studies
- Child, Preschool
- Enterovirus A, Human
(immunology)
- Female
- Hand, Foot and Mouth Disease
(diagnosis, immunology, virology)
- Humans
- Immunity, Cellular
- Infant
- Interleukin-4
(immunology)
- Male
- Prognosis
- Th2 Cells
(immunology)
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