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Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease.

Abstract
The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells following antigen stimulation in vitro tended to have a more prolonged period of high fevers and a longer duration of illness. Thus, an increase of EV71 epitope-specific Th2 type response may portend the poor prognosis for some HFMD patients.
AuthorsRuicheng Wei, Lijuan Xu, Na Zhang, Kai Zhu, Juhao Yang, Chunhui Yang, Chaoyang Deng, Zhaomin Zhu, Anne S De Groot, Ralf Altmeyer, Mei Zeng, Qibin Leng
JournalVirus research (Virus Res) Vol. 177 Issue 1 Pg. 62-5 (Oct 2013) ISSN: 1872-7492 [Electronic] Netherlands
PMID23886670 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Interleukin-4
Topics
  • Case-Control Studies
  • Child, Preschool
  • Enterovirus A, Human (immunology)
  • Female
  • Hand, Foot and Mouth Disease (diagnosis, immunology, virology)
  • Humans
  • Immunity, Cellular
  • Infant
  • Interleukin-4 (immunology)
  • Male
  • Prognosis
  • Th2 Cells (immunology)

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