Abstract |
A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecular weight proteins. The case illustrates the crucial role of electron microscopy as well as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.
|
Authors | Fernando C Fervenza |
Journal | Clinical journal of the American Society of Nephrology : CJASN
(Clin J Am Soc Nephrol)
Vol. 8
Issue 11
Pg. 1979-87
(Nov 2013)
ISSN: 1555-905X [Electronic] United States |
PMID | 23886564
(Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- CLC-5 chloride channel
- Chloride Channels
- Sodium Chloride Symporter Inhibitors
- Creatinine
|
Topics |
- Adolescent
- Biomarkers
(blood)
- Biopsy
- Chloride Channels
(genetics)
- Creatinine
(blood)
- Dent Disease
(blood, complications, diagnosis, drug therapy, genetics)
- Frameshift Mutation
- Genetic Predisposition to Disease
- Glomerulosclerosis, Focal Segmental
(blood, diagnosis, drug therapy, etiology)
- Humans
- Hypercalciuria
(etiology)
- Male
- Nephrosis
(blood, diagnosis, drug therapy, etiology)
- Phenotype
- Predictive Value of Tests
- Proteinuria
(blood, diagnosis, drug therapy, etiology)
- Sodium Chloride Symporter Inhibitors
(therapeutic use)
- Treatment Outcome
|