Study of methacholine positivity in patients with chronic cough at Masih Daneshvari hospital, Tehran, 2007-2008.

Abstract

While airways reactivity is among the characteristics of asthma, it is not considered a sufficient condition diagnostically and the methacholine challenge is a non-specific diagnostic aid in cases of chronic cough and reactive airways disease. The aim of this cross-sectional study was to determine the metacholine response positivity and diagnosis of asthma in patients with chronic cough presenting to a hospital in Tehran during 2007 and 2008. Of 101 patients with chronic cough (with no history of sinusitis, recent pulmonary infection, bronchitis, gasteroesophageal reflux or underlying pulmonary conditions), 51.5% showed reactive airways disease to the methacholine test, 40.6% were unreactive and 7.9% were indeterminate. A positive methacholine challenge test was positively correlated with new wheezing. Although the methacholine challenge test is not a primary test for evaluating chronic cough, if no other reason for chronic cough is found, it may be a guiding test for asthma.

• Authors: A Cheraghvandi, L Fadaizadeh, S A Taheri, M R Masjedi
• Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (East Mediterr Health J) Vol. 19 Issue 4 Pg. 369-72 (Apr 2013) ISSN: 1020-3397 [Print] Egypt
• PMID: 23882963 (Publication Type: Journal Article)

Chemical References

• Methacholine Chloride

Topics

• Adolescent
• Adult
• Aged
• Asthma (diagnosis, epidemiology)
• Bronchial Hyperreactivity (diagnosis, epidemiology, metabolism)
• Bronchial Provocation Tests
• Chronic Disease
• Cough (epidemiology, metabolism)
• Cross-Sectional Studies
• Female
• Humans
• Iran (epidemiology)
• Male
• Methacholine Chloride (metabolism)
• Middle Aged
• Respiratory Function Tests
• Respiratory Sounds
• Young Adult