[Treatment of cystoid macular edema with bevacizumab in course of Irvine-Gass syndrome].

Abstract

PURPOSE:

To determine clinical effect of intravitreal bevacizumab (Avastin) in patients with cystoid macular edema after cataract surgery.

MATERIAL AND METHODS:

Four eyes of four patients treated with 1 intravitreal injection of 1.25 mg Avastin. In three cases duration of cystoid macular edema was less then 4 months, in one eye cystoid macular edema was chronic (more than 4 months). Visual acuity and clinical effect in spectral optical coherence tomography (central retinal thickness and fovea anatomy) was examined before and after intravitreal injection.

RESULTS:

Visual acuity improved in 3 of 4 patients. In acute cystoid macular edema final visual acuity was 0.8-0.9, in chronic cystoid macular edema patient visual acuity improved from 0.05 to 0.2. In 3 of 4 patients central retinal thickness decreased and fovea anatomy was normalized. In patient with no clinical and anatomical improvement spectral optical coherence tomography examination revealed epiretinal membrane.

CONCLUSIONS:

Intravitreal Avastin may be successful treatment in most Irvine-Gass syndrome cases. The condition that exclude patients from bevacizumab treatment is horizontal (epiretinal membrane), and vertical traction revealed in spectral optical coherence tomography.

• Authors: Bartosz Izdebski, Zofia Michalewska, Krzysztof Dziegielewski, Jerzy Nawrocki, Dominik Odrobina
• Journal: Klinika oczna (Klin Oczna) Vol. 115 Issue 1 Pg. 61-4 ( 2013) ISSN: 0023-2157 [Print] Poland
• Vernacular Title: Zastosowanie bewacyzumabu w leczeniu torbielowatego obrzeku plamki w przebiegu zespoiu Irvina-Gassa.
• PMID: 23882744 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal, Humanized
• Bevacizumab

Topics

• Aged
• Aged, 80 and over
• Angiogenesis Inhibitors (administration & dosage)
• Antibodies, Monoclonal, Humanized (administration & dosage)
• Bevacizumab
• Female
• Fluorescein Angiography
• Humans
• Intravitreal Injections
• Macular Edema (diagnosis, drug therapy)
• Male
• Middle Aged
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Acuity (drug effects)