Abstract | BACKGROUND: METHODS: In this nationwide population-based cohort study, we included 12,332 patients with established coronary heart disease who underwent primary isolated coronary artery bypass grafting in Sweden between 2005 and 2008. Medication use was retrieved from the national Prescribed Drug Register. RESULTS: During the first year after coronary surgery, 94% of patients had at least two dispensed prescriptions for an antiplatelet agent, 68% for an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, 92% for a beta-blocker, and 93% for a statin. Only 57% of all patients had prescriptions for all four medication classes. Reduced renal function (estimated glomerular filtration rate (eGFR) of 30 to 45 mL/min per 1.73 m(2) and <30 mL/min per 1.73 m(2)) was significantly associated with a lower use of all four medication classes (adjusted risk ratio 0.89, 95% confidence interval 0.82 to 0.98; and adjusted risk ratio 0.75, 95% confidence interval 0.62 to 0.90, respectively) as compared to normal renal function (eGFR >60 mL/min per 1.73 m(2)). CONCLUSIONS: In patients with established coronary heart disease, moderate to severe renal dysfunction was associated with significantly lower use of guideline-recommend medications as compared to normal renal function.
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Authors | Ulrik Sartipy, Erik Rampell, Axel C Carlsson, Per Wändell, Martin J Holzmann |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 168
Issue 4
Pg. 4033-8
(Oct 09 2013)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 23880581
(Publication Type: Journal Article)
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Copyright | © 2013. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cardiovascular Agents
(pharmacology, therapeutic use)
- Cohort Studies
- Coronary Artery Bypass
(adverse effects, trends)
- Coronary Artery Disease
(drug therapy, epidemiology, surgery)
- Female
- Glomerular Filtration Rate
(physiology)
- Humans
- Kidney
(drug effects, physiology)
- Male
- Middle Aged
- Population Surveillance
(methods)
- Retrospective Studies
- Sweden
(epidemiology)
- Treatment Outcome
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