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Cyclical thrombocytosis, acquired von Willebrand syndrome and aggressive non-melanoma skin cancers are common in patients with Philadelphia-negative myeloproliferative neoplasms treated with hydroxyurea.

Abstract
Abstract Cyclical thrombocytosis, acquired von Willebrand syndrome, aggressive non-melanoma skin cancers and other hydroxyurea complications have been reported in Philadelphia-negative myeloproliferative neoplasms (MPNs), but their incidence and clinical consequences have not been defined in a large cohort of patients. We conducted a retrospective analysis of 188 consecutive patients with MPNs specifically addressing the incidence of these complications. Cyclical thrombocytosis was documented in 29 patients (15%), the majority of whom were receiving hydroxyurea. Acquired von Willebrand syndrome was identified in 17 of the 84 screened patients (20%), but was not associated with any major bleeding complications. Non-melanoma skin cancers were reported in 51 patients (27%). Hydroxyurea-related fever occurred in nine of 149 patients (6%) who received hydroxyurea. Seventy-three patients (39%) experienced a total of 98 major thrombotic events, with the majority of these occurring prior to or within 3 months of the diagnosis. Cyclical thrombocytosis, acquired von Willebrand syndrome, aggressive non-melanoma skin cancers and other hydroxyurea-related complications are not infrequent in MPNs and have important clinical consequences for management.
AuthorsEmma Verner, Cecily Forsyth, Andrew Grigg
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 55 Issue 5 Pg. 1139-43 (May 2014) ISSN: 1029-2403 [Electronic] United States
PMID23879199 (Publication Type: Journal Article)
Chemical References
  • Janus Kinase 2
  • Hydroxyurea
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Hydroxyurea (adverse effects, therapeutic use)
  • Janus Kinase 2 (genetics)
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (complications, drug therapy, genetics)
  • Male
  • Middle Aged
  • Myeloproliferative Disorders
  • Periodicity
  • Platelet Count
  • Skin Neoplasms (diagnosis, etiology)
  • Thrombocytosis (diagnosis, etiology)
  • Thrombosis (etiology)
  • von Willebrand Diseases (diagnosis, etiology)

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