Abstract |
Imidazolium oximes are useful in the treatment of organophosphorus agent poisoning. However, the extant methods for analyzing oximes in plasma and urine samples are not adequate. A unique high-performance liquid chromatographic assay method was developed for quantitating either imidazolium or pyridinium oximes. Plasma or urine samples can be injected directly onto the column after a centrifugation filtration step. This method demonstrates a different approach in the method development for quaternary ammonium compounds using non-end-capped reversed-phase columns and a mobile phase containing competing cations. In addition, a preliminary pharmacokinetic study of the imidazolium oxime in rabbits was carried out using this method.
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Authors | M L Shih, J R Smith, G W Salem |
Journal | Journal of chromatography
(J Chromatogr)
Vol. 527
Issue 2
Pg. 371-9
(May 18 1990)
Netherlands |
PMID | 2387884
(Publication Type: Journal Article)
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Chemical References |
- Imidazoles
- Oximes
- Pyridinium Compounds
- WR 254416
- WR 255737
- N,N'-monomethylenebis(pyridiniumaldoxime)
- asoxime chloride
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Topics |
- Animals
- Chromatography, High Pressure Liquid
- Half-Life
- Imidazoles
(analysis, blood, urine)
- Microchemistry
- Oximes
(analysis, blood, urine)
- Pyridinium Compounds
(analysis, blood, urine)
- Quality Control
- Rabbits
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