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Lamotrigine for intractable migraine-like headaches in Sturge-Weber syndrome.

Abstract
We herein report that naratriptan remarkably improved intractable migraine-like headaches in a patient with Sturge-Weber syndrome (SWS) despite his past history of cerebral infarction. In addition, lamotrigine had a prophylactic effect on his visual aura and headaches. An 18-year-old male patient with SWS had intractable migraine-like headaches every several months from the age of 3years. His migraine-like headaches were characterized by pulsating attacks preceded by left homonymous hemianopsia, which persisted after headache disappearance. In addition, after 14years of age, the pulsating headaches were preceded by photophobia without homonymous hemianopsia and occurred almost daily. Headache pains were not improved by acetaminophen or loxoprofen sodium hydrate. Furthermore, various prophylactic drugs were ineffective. After obtaining informed consent, naratriptan was administered. The pain severity was reduced and the duration of headache with homonymous hemianopsia was shortened from several days to several hours. Interestingly, naratriptan also shortened the duration of homonymous hemianopsia to several hours. We confirmed that his headache attacks were not epileptic seizures by ictal electroencephalography. However, 25mg/day of lamotrigine had a prophylactic effect on the frequency of headache. Moreover, lamotrigine led to complete remission of his headache without homonymous hemianopsia. Lamotrigine may have an advantage in terms of reducing the risk of cerebrovascular disease caused by migraine-like headaches and the use of triptans. The most effective management for migraine-like headaches in patients with SWS has not been established. Lamotrigine is a potentially effective option for patients with SWS with migraine-like headaches.
AuthorsShohei Nomura, Shuichi Shimakawa, Miho Fukui, Takuya Tanabe, Hiroshi Tamai
JournalBrain & development (Brain Dev) Vol. 36 Issue 5 Pg. 399-401 (May 2014) ISSN: 1872-7131 [Electronic] Netherlands
PMID23877022 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Analgesics, Non-Narcotic
  • Triazines
  • Lamotrigine
Topics
  • Adolescent
  • Analgesics, Non-Narcotic (therapeutic use)
  • Cognition (drug effects)
  • Headache (drug therapy, etiology)
  • Humans
  • Lamotrigine
  • Male
  • Neuropsychological Tests
  • Remission Induction
  • Sturge-Weber Syndrome (complications)
  • Triazines (therapeutic use)

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