Lateral and dorsal column hyperintensity on magnetic resonance imaging in a patient with myelopathy associated with intrathecal chemotherapy.

Abstract

Chemotherapy-related myelopathy mimicking subacute combined degeneration (SCD) has rarely been reported. We encountered a 35-year-old female with sensory ataxia after intrathecal chemotherapy. Spinal magnetic resonance imaging showed localized abnormal signal areas in the lateral and dorsal white matter, mimicking SCD. Diffusion imaging showed restricted water diffusion and increased microstructural complexity, and cerebrospinal fluid analysis showed increased levels of myelin basic proteins, indicating demyelinating myelopathy. Advanced diffusion imaging can provide more information on the microstructure of chemotherapy-related myelopathy.

• Authors: Fumine Saito, Taku Hatano, Masaaki Hori, Miwako Kawamura, Makoto Sasaki, Shigeki Aoki, Nobutaka Hattori
• Journal: Case reports in neurology (Case Rep Neurol) Vol. 5 Issue 2 Pg. 110-5 (May 2013) ISSN: 1662-680X [Print] Switzerland
• PMID: 23874296 (Publication Type: Case Reports)