[The anti-arrhythmia activity and effect on the heart conduction system of the new anti-arrhythmia preparation bonnecor].
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| Abstract |
In 10 patients with frequent ventricular extrasystoles there were studied the antiarrhythmic effectiveness and side effects of a new drug bonnecor at a single intravenous administration in doses from 15 to 60 mg (0.17-0.91 mg/kg). It was found that the drug exerted the antiarrhythmic effect at dosages of over 0.4 mg/kg and side effects and toxic effects occurred at dosages of over 0.7 mg/kg. The optimal dose for a single intravenous administration was regarded to be the dose of 0.6 mg/kg. The mechanisms of action of bonnecor were studied during intracardiac electrophysiological investigation. The drug was shown to suppress the conduction of excitation along the atrioventricular node, the His-Purkinje system, the ventricular myocardium and the abnormal pathways of conduction. Thus, bonnecor may be referred to as an agent of class I according to the classification of Vaughan Williams. When administered intravenously (0.6 mg/kg) bonnecor was found to interrupt and prevent the recurrent development of atrioventricular tachycardia and also supraventricular tachycardias at the presence of the abnormal pathways of conduction.
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| Authors | S F Sokolov, S P Golitsyn, V I Malakhov, V A Bankuzov, M I Koltunova, L S Golitsyn |
| Journal | Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 May-Jun Vol. 53 Issue 3 Pg. 57-60 ISSN: 0014-8318 [Print] Russia (Federation) |
| Vernacular Title | Antiaritmicheskaia aktivnost' i vliianie na provodiashchuiu sistemu serdtsa novogo antiaritmicheskogo preparata bonnekora. |
| PMID | 2387385 (Publication Type: Comparative Study, English Abstract, Journal Article) |
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