[The effect of bonnecor on cardiac hemodynamics, blood supply and function in experimental myocardial ischemia].

Abstract

The effect of a new antiarrhythmic drug bonnecor on the hemodynamics, blood supply and function of the ischemic heart as compared with the famous antiarrhythmic drugs lidocaine and ethacizine was studied in the experiments on anesthetized animals (rats, dogs) under artificial respiration. It was shown that bonnecor administered in a dose of 0.5 mg/kg was able of relieving disturbances of the cardiac hemodynamics and function produced by occlusion of the coronary artery. The drug exerted no significant effect on the blood supply to the focus of acute and chronic myocardial ischemia.

• Authors: G G Chichkanov, E A Tolmacheva, V V Lyskovtsev, E K Grigor'eva, D D Matsievskiĭ
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 May-Jun Vol. 53 Issue 3 Pg. 38-40 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie bonnekora na gemodinamiku, krovoobrashchenie i funktsiiu serdtsa pri éksperimental'noĭ ishemii miokarda.
• PMID: 2387378 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Dibenzazepines
• Phenothiazines
• Lidocaine
• tiracizine
• ethacizine

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Coronary Circulation (drug effects, physiology)
• Coronary Disease (drug therapy, physiopathology)
• Dibenzazepines (therapeutic use)
• Dogs
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Heart (drug effects, physiopathology)
• Hemodynamics (drug effects, physiology)
• Lidocaine (therapeutic use)
• Male
• Phenothiazines (therapeutic use)
• Rats
• Time Factors