[The anti-arrhythmia activity of quinazopyrine].

Abstract

The antiarrhythmic activity of quinasopirine was studied in the experiments on rats with the use of models of calcium chloride- and aconitine-induced arrhythmias, disorders of cardiac rhythm in myocardial infarction produced by isadrine and pituitrin and also in the experiments on cats in arrhythmias caused by electric stimulation of the myocardium, postinfarction and reperfusion arrhythmias. Quinasopirine exhibits the antiarrhythmic effect being superior to that of anapriline and novocainamide in arrhythmias induced by calcium chloride and aconitine. In other types of the cardiac rhythm disorder its activity is comparable with that of ethmosine, obsidane and cordarone. Quinasopirine reduces automatism and contractile function of the myocardium.

• Authors: V R Stets, E G Beregovaia, V V Dunaev, B G Storozhuk, V N Favoritov, A A Stoliarchuk, A I Mazur
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 May-Jun Vol. 53 Issue 3 Pg. 15-7 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Issledovanie antiaritmicheskoĭ aktivnosti khinazopirina.
• PMID: 2387373 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Quinazolines
• quinazopyrine
• Propranolol
• Procainamide

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (chemically induced, drug therapy)
• Cats
• Drug Evaluation, Preclinical
• Female
• Male
• Myocardial Infarction (chemically induced, drug therapy)
• Procainamide (therapeutic use)
• Propranolol (therapeutic use)
• Quinazolines (therapeutic use)
• Rats
• Rats, Inbred Strains
• Ventricular Fibrillation (drug therapy, etiology)