Analysis of the complete genome of the first Irkut virus isolate from China: comparison across the Lyssavirus genus.

Abstract

The genome of Irkut virus, isolate IRKV-THChina12, the first non-rabies lyssavirus from China (of bat origin), has been completely sequenced. In general, coding and non-coding regions of this viral genome are similar to those of other lyssaviruses. However, alignment of the deduced amino acid sequences of the structural proteins of IRKV-THChina12 with those of other lyssavirus representatives revealed significant variability between viral species. The nucleoprotein and matrix protein were found to be the most conserved, followed by the large protein, glycoprotein and phosphoprotein. Differences in the antigenic sites in glycoprotein may result in only partial protection of the available rabies biologics against Irkut virus, which is of particular concern for pre- and post-exposure rabies prophylaxis.

• Authors: Ye Liu, Nan Li, Shoufeng Zhang, Fei Zhang, Hai Lian, Ying Wang, Jinxia Zhang, Rongliang Hu
• Journal: Molecular phylogenetics and evolution (Mol Phylogenet Evol) Vol. 69 Issue 3 Pg. 687-93 (Dec 2013) ISSN: 1095-9513 [Electronic] United States
• PMID: 23872529 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Nucleoproteins
• Viral Matrix Proteins

Topics

• Amino Acid Sequence
• Animals
• China
• Chiroptera (virology)
• Genome, Viral
• Lyssavirus (genetics)
• Nucleoproteins (genetics)
• Phylogeny
• Sequence Alignment
• Sequence Analysis, DNA
• Viral Matrix Proteins (genetics)