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Absence of post-transplantation lymphoproliferative disorder after allogeneic blood or marrow transplantation using post-transplantation cyclophosphamide as graft-versus-host disease prophylaxis.

Abstract
Immunosuppressive regimens that effectively prevent graft-versus-host disease (GVHD) after allogeneic blood or marrow transplantation (allo-BMT) have been associated with an increased incidence of post-transplantation lymphoproliferative disorder (PTLD) in the first year after transplantation. We evaluated the incidence of PTLD associated with the use of high-dose post-transplantation cyclophosphamide (PTCy) as GVHD prophylaxis. Between 2000 and 2011, a total of 785 adult allo-BMT recipients were given PTCy as GVHD prophylaxis at the Johns Hopkins Hospital, including 313 patients who received PTCy as sole GVHD prophylaxis. HLA-haploidentical or unrelated donor graft transplantation was performed in 526 patients (67%). No cases of PTLD occurred during the first year after allo-BMT in this series. PTLD is a rare occurrence after allo-BMT using PTCy, even in high-risk alternative donor transplantations.
AuthorsJennifer A Kanakry, Yvette L Kasamon, Javier Bolaños-Meade, Ivan M Borrello, Robert A Brodsky, Ephraim J Fuchs, Nilanjan Ghosh, Douglas E Gladstone, Christopher D Gocke, Carol Ann Huff, Christopher G Kanakry, Leo Luznik, William Matsui, Huzefa J Mogri, Lode J Swinnen, Heather J Symons, Richard J Jones, Richard F Ambinder
JournalBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 19 Issue 10 Pg. 1514-7 (Oct 2013) ISSN: 1523-6536 [Electronic] United States
PMID23871780 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Antineoplastic Agents, Alkylating
  • Immunosuppressive Agents
  • Cyclophosphamide
Topics
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Agents, Alkylating (therapeutic use)
  • Bone Marrow Transplantation (methods)
  • Cyclophosphamide (therapeutic use)
  • Female
  • Graft vs Host Disease (drug therapy, prevention & control)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Lymphoma (drug therapy, surgery, therapy)
  • Male
  • Middle Aged
  • Transplantation, Homologous (methods)
  • Young Adult

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