Managing uncontrolled postsplenectomy reactive thrombocytosis in idiopathic thrombocytopenic purpura: role of thrombocytapheresis.

Reactive thrombocytosis occurs in response to infection, trauma, or surgery. Splenectomy alone accounts for 19% of all possible causes of extreme thrombocytosis. We performed thrombocytapheresis in a young lady with chronic idiopathic thrombocytopenic purpura (ITP) who developed postsplenectomy reactive thrombocytosis. Her post splenectomy platelet count was 227 × 10(6)/ml which elevated to 1623 × 10(6)/ml on the 7th postoperative day. A single thrombocytapheresis procedure reduced her platelet to 403 × 10(6)/ml. She was discharged on the 10th postoperative day and then maintained a count of 204-238 × 10(6)/ml with aspirin. Thrombocytapheresis reduces the platelet count rapidly in thrombocytosis and prevents patients from having thrombotic events. However, such procedures should be performed very meticulously to ensure patient safety.
AuthorsSudipta Sekhar Das, Soumya Bhattacharya, Subrata Sen
JournalTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 49 Issue 2 Pg. 171-3 (Oct 2013) ISSN: 1473-0502 [Print] England
PMID23871583 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
  • Adult
  • Female
  • Humans
  • Plateletpheresis
  • Postoperative Complications (etiology, therapy)
  • Purpura, Thrombocytopenic (pathology, surgery)
  • Splenectomy (adverse effects)
  • Thrombocytosis (etiology, therapy)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: