Abstract |
Piperine is a bioactive component of black pepper, Piper nigrum Linn, commonly used for daily consumption and in traditional medicine. Here, the molecular mechanisms by which piperine exerts antitumor effects in HER2-overexpressing breast cancer cells was investigated. The results showed that piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage. Furthermore, piperine inhibited HER2 gene expression at the transcriptional level. Blockade of ERK1/2 signaling by piperine significantly reduced SREBP-1 and FAS expression. Piperine strongly suppressed EGF-induced MMP-9 expression through inhibition of AP-1 and NF-κB activation by interfering with ERK1/2, p38 MAPK, and Akt signaling pathways resulting in a reduction in migration. Finally, piperine pretreatment enhanced sensitization to paclitaxel killing in HER2-overexpressing breast cancer cells. Our findings suggest that piperine may be a potential agent for the prevention and treatment of human breast cancer with HER2 overexpression.
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Authors | Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Tilak Khanal, Bong Hwan Park, Thu Phuong Tran, Tae Cheon Jeong, Hye Gwang Jeong |
Journal | Food chemistry
(Food Chem)
Vol. 141
Issue 3
Pg. 2591-9
(Dec 01 2013)
ISSN: 1873-7072 [Electronic] England |
PMID | 23870999
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Alkaloids
- Antineoplastic Agents, Phytogenic
- Benzodioxoles
- Piperidines
- Plant Extracts
- Polyunsaturated Alkamides
- ERBB2 protein, human
- Receptor, ErbB-2
- p38 Mitogen-Activated Protein Kinases
- Caspase 3
- piperine
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Topics |
- Alkaloids
(pharmacology)
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Apoptosis
(drug effects)
- Benzodioxoles
(pharmacology)
- Breast Neoplasms
(drug therapy, genetics, metabolism, physiopathology)
- Caspase 3
(genetics, metabolism)
- Female
- Gene Expression Regulation, Neoplastic
(drug effects)
- Humans
- Piperidines
(pharmacology)
- Plant Extracts
(pharmacology)
- Polyunsaturated Alkamides
(pharmacology)
- Receptor, ErbB-2
(genetics, metabolism)
- Signal Transduction
(drug effects)
- p38 Mitogen-Activated Protein Kinases
(genetics, metabolism)
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