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Effectiveness of an oxidized cellulose patch hemostatic agent in thyroid surgery: a prospective, randomized, controlled study.

AbstractBACKGROUND:
This single-blinded, prospective, randomized controlled trial compared the efficacy and safety of an oxidized cellulose patch (Surgicel [Johnson and Johnson]) with conventional procedures for achieving hemostasis in thyroid surgery.
STUDY DESIGN:
The study included 190 patients scheduled for thyroidectomy. Patients were randomized into 1 conventionally treated (ligatures and bipolar electrocautery) group (n = 92) and a second group, which additionally received Surgicel (n = 98).
RESULTS:
The groups were demographically and clinically matched and had similar wound drainage volumes and mean duration of surgery. Postoperative bleeding rate was greater in the Surgicel group, yet the difference didn't reach statistical significance (p = 0.054). There were no significant group differences in postoperative wound infection, seroma, hypocalcemia, or recurrent laryngeal nerve palsy. Time to drain removal and length of hospital stay were significantly shorter in the conventional group (p < 0.001).
CONCLUSIONS:
Routine use of an oxidized cellulose hemostatic agent has no advantage over conventional hemostasis and is potentially harmful in thyroid surgery.
AuthorsMoran Amit, Yoav Binenbaum, Jacob T Cohen, Ziv Gil
JournalJournal of the American College of Surgeons (J Am Coll Surg) Vol. 217 Issue 2 Pg. 221-5 (Aug 2013) ISSN: 1879-1190 [Electronic] United States
PMID23870217 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
CopyrightCopyright © 2013 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Cellulose, Oxidized
  • Hemostatics
  • Surgicel
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Loss, Surgical (prevention & control)
  • Cellulose, Oxidized (therapeutic use)
  • Electrocoagulation
  • Female
  • Hemostasis, Surgical (methods)
  • Hemostatics (therapeutic use)
  • Humans
  • Length of Stay (statistics & numerical data)
  • Ligation
  • Male
  • Middle Aged
  • Postoperative Hemorrhage (prevention & control)
  • Prospective Studies
  • Single-Blind Method
  • Thyroidectomy
  • Treatment Outcome

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