HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The impact of drug discontinuation in patients treated with temporary pacemaker due to atrioventricular block.

AbstractINTRODUCTION:
Patients treated with a temporary pacemaker (TPM) due to atrioventricular (AV) block are often monitored after discontinuation of AV node blocking drugs to evaluate the indication for permanent pacing. However, the impact of drug discontinuation is sparsely documented. We investigated to what extent drug discontinuation abolished the need for permanent pacemaker (PPM) implantation.
METHODS AND RESULTS:
All hospital records of patients who received a TPM at Aalborg Hospital, Denmark, between January 2000 and March 2011 (n = 575) were retrospectively reviewed. Patients with AV block who were treated with a TPM and concomitant cessation of drug therapy were included if there was no other underlying mechanism causing the AV block. AV blocking drugs included antiarrhythmic agents classes II-IV and digoxin. Fifty-five patients fulfilled our inclusion criteria. Forty-seven patients had an indication for a PPM at the initial hospital admission, despite drug discontinuation. Of the remaining 8 patients who were discharged without a PPM, 3 subsequently experienced events: 2 had recurrence of AV block requiring a PPM, and 1 experienced syncope. Thus, in total, 49 (89%) patients had a final indication for a permanent pacemaker (PPM). Of patients receiving beta-blocker monotherapy, 26 (96%) had an indication for a PPM. TPM implantation was complicated by infection or displacement in 11% of cases.
CONCLUSIONS:
The vast majority of patients treated with a TPM due to AV block and who receive beta-blockers alone or in combination with digoxin have a final indication for a PPM despite cessation of drug treatment. TPM are frequently associated with complications.
AuthorsMaria Bisgaard Knudsen, Anna Margrethe Thøgersen, Søren Pihlkjaer Hjortshøj, Sam Riahi
JournalJournal of cardiovascular electrophysiology (J Cardiovasc Electrophysiol) Vol. 24 Issue 11 Pg. 1255-8 (Nov 2013) ISSN: 1540-8167 [Electronic] United States
PMID23869746 (Publication Type: Journal Article)
Copyright© 2013 Wiley Periodicals, Inc.
Chemical References
  • Anti-Arrhythmia Agents
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Arrhythmia Agents (administration & dosage)
  • Atrioventricular Block (diagnosis, physiopathology, therapy)
  • Atrioventricular Node (drug effects, physiopathology)
  • Cardiac Pacing, Artificial (adverse effects)
  • Denmark
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Pacemaker, Artificial
  • Patient Admission
  • Patient Discharge
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: