HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Unilateral or bilateral vagotomy induces ovulation in both ovaries of rats with polycystic ovarian syndrome.

AbstractBACKGROUND:
Injecting estradiol valerate (EV) to pre-pubertal or adult female rat results in effects similar to those observed in women with polycystic ovarian syndrome (PCOS). One of the mechanisms involved in PCOS development is the hyperactivity of the sympathetic nervous system. In EV-induced PCOS rats, the unilateral sectioning of the superior ovarian nerve (SON) restores ovulation of the innervated ovary. This suggests that, in addition to the sympathetic innervation, other neural mechanisms are involved in the development/maintenance of PCOS. The aims of present study were analyze if the vagus nerve is one of the neural pathways participating in PCOS development.
METHODS:
Ten-day old rats were injected with EV dissolved in corn oil. At 24-days of age sham-surgery, unilateral, or bilateral sectioning of the vagus nerve (vagotomy) was performed on these rats. The animals were sacrificed at 90-92 days of age, when they presented vaginal estrous preceded by a pro-estrus smear.
RESULTS:
In EV-induced PCOS rats, unilateral or bilateral vagotomy restored ovulation in both ovaries. Follicle-stimulating hormone (FSH) levels in PCOS rats with unilateral or bilateral vagotomy were lower than in control rats.
CONCLUSIONS:
This result suggests that in EV-induced PCOS rats the vagus nerve is a neural pathway participating in maintaining PCOS. The vagus nerve innervates the ovaries directly and indirectly through its synapsis in the celiac-superior-mesenteric ganglion, where the somas of neurons originating in the SON are located. Then, it is possible that vagotomy effects in EV-induced PCOS rats may be explained as a lack of communication between the central nervous system and the ovaries.
AuthorsRosa Linares, Denisse Hernández, Carolina Morán, Roberto Chavira, Mario Cárdenas, Roberto Domínguez, Leticia Morales-Ledesma
JournalReproductive biology and endocrinology : RB&E (Reprod Biol Endocrinol) Vol. 11 Pg. 68 ( 2013) ISSN: 1477-7827 [Electronic] England
PMID23866168 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Gonadal Steroid Hormones
  • Gonadotropins
  • Steroids
Topics
  • Animals
  • Estrous Cycle (physiology)
  • Female
  • Gonadal Steroid Hormones (biosynthesis)
  • Gonadotropins (biosynthesis)
  • Neural Pathways (physiology)
  • Ovary (pathology, physiopathology)
  • Ovulation (physiology)
  • Polycystic Ovary Syndrome (pathology, physiopathology)
  • Rats
  • Steroids (biosynthesis)
  • Vagotomy
  • Vagus Nerve (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: