PPARγ and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk.

Abstract

CONTEXT:

Breast cancer (BC) risk has been differentially associated with urinary levels of some phthalate metabolites.

OBJECTIVE:

To investigate whether PPARγ and PPARGC1B polymorphisms modulate these associations.

MATERIALS AND METHODS:

208 BC cases were age-matched with 220 population controls. Phthalate metabolites were determined by HPLC-MS. PPARγ Pro12Ala (rs1801281) and PPARGC1B Ala203Pro (rs7732671) and Val279Ile (rs17572019) were genotyped.

RESULTS:

The association between mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and BC risk was positively modified in PPARγ Pro12Ala C carriers. The association with mono-iso-butyl phthalate (MiBP) in PPARGC1B Ala203Pro G carriers was negatively modified.

CONCLUSION:

PPARγ and PPARGC1B polymorphisms modulate the association between phthalate exposure and BC risk.

• Authors: Gabriela A Martínez-Nava, Ana I Burguete-García, Lizbeth López-Carrillo, Raúl U Hernández-Ramírez, Vicente Madrid-Marina, Mariano E Cebrián
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 18 Issue 6 Pg. 493-501 (Sep 2013) ISSN: 1366-5804 [Electronic] England
• PMID: 23866026 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• PPAR gamma
• PPARGC1B protein, human
• Phthalic Acids
• RNA-Binding Proteins

Topics

• Breast Neoplasms (genetics, metabolism)
• Carrier Proteins (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• PPAR gamma (genetics)
• Phthalic Acids (metabolism, urine)
• Polymorphism, Single Nucleotide
• RNA-Binding Proteins