Abstract | BACKGROUND: Moderately elevated unconjugated bilirubin concentrations protect against inflammatory diseases and are present in individuals with Gilbert's syndrome. This study examined the relationship between circulating haem oxygenase catabolites, unconjugated bilirubin, carboxy haemoglobin, iron and inflammatory parameters. MATERIALS AND METHODS: RESULTS:
Gilbert's syndrome subjects had significantly greater levels of unconjugated bilirubin (P < 0.05), carboxy haemoglobin (P < 0.05), iron (P < 0.05), IL-1β (P < 0.05), a significantly lower body mass index (P < 0.05) and IL-6 concentrations (P < 0.05) vs. controls. Regression analysis revealed that unconjugated bilirubin mainly explained IL-1β results (16%), and body mass index+IL-6 predicted 26% of the variance in C-reactive protein concentrations. CONCLUSIONS:
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Authors | Marlies Wallner, Andrew C Bulmer, Christine Mölzer, Elisabeth Müllner, Rodrig Marculescu, Daniel Doberer, Michael Wolzt, Oswald F Wagner, Karl-Heinz Wagner |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 43
Issue 9
Pg. 912-9
(Sep 2013)
ISSN: 1365-2362 [Electronic] England |
PMID | 23865893
(Publication Type: Journal Article)
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Copyright | © 2013 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. |
Chemical References |
- Interleukin-1beta
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Heme
- C-Reactive Protein
- Carboxyhemoglobin
- Heme Oxygenase (Decyclizing)
- Bilirubin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bilirubin
(metabolism)
- C-Reactive Protein
(metabolism)
- Carboxyhemoglobin
(metabolism)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Gilbert Disease
(blood)
- Heme
(metabolism)
- Heme Oxygenase (Decyclizing)
(metabolism)
- Humans
- Interleukin-1beta
(metabolism)
- Interleukin-6
(metabolism)
- Male
- Middle Aged
- Tumor Necrosis Factor-alpha
(metabolism)
- Young Adult
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