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Nanostructuring the surface of dual responsive hollow polymer microspheres for versatile utilization in nanomedicine-related applications.

Abstract
The design and fabrication of hollow polymer microspheres responsive to various stimuli comprises a promising approach for the development of multifunctional and efficient systems for various nanomedicine-related applications. In this paper, we present the preparation of poly(methacrylic acid-co-N,N'-methylenebis(acrylamide)-co-poly(ethylene glycol) methyl ether methacrylate-co-N,N'-bis(acryloyl)cystamine) (PMAA(S-S)) hollow microspheres following a two-stage distillation precipitation polymerization procedure. Magnetic and silver nanocrystals were chemically grown on the surface of the hollow polymer microspheres, resulting in a composite system with interesting properties. We evaluated the performance of the composite hollow microspheres as magnetic hyperthermia mediators and their surface-enhanced Raman spectroscopy activity. Assessment of Daunorubicin-loaded PMAA(S-S) hollow microspheres performance as effective drug carriers was carried out through drug release experiments upon application of different pH and reducing conditions. pH and redox responsiveness as well as basic mechanisms of release profiles are discussed. Furthermore, in vitro cytotoxicity of empty and drug-loaded PMAA(S-S) hollow microspheres against MCF-7 cancer cells was investigated in order to evaluate their performance as drug carriers.
AuthorsA Chatzipavlidis, P Bilalis, L-A Tziveleka, N Boukos, C A Charitidis, G Kordas
JournalLangmuir : the ACS journal of surfaces and colloids (Langmuir) Vol. 29 Issue 30 Pg. 9562-72 (Jul 30 2013) ISSN: 1520-5827 [Electronic] United States
PMID23862698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Carriers
  • Magnetite Nanoparticles
  • Polymers
  • Polymethacrylic Acids
  • poly(methacrylic acid-co-N,N'-methylenebis(acrylamide)-co-poly(ethylene glycol) methyl ether methacrylate-co-N,N'-bis(acryloyl)cystamine)
  • Silver
  • Daunorubicin
Topics
  • Chemical Precipitation
  • Daunorubicin (chemistry, pharmacology)
  • Drug Carriers (chemical synthesis, chemistry)
  • Hydrogen-Ion Concentration
  • MCF-7 Cells
  • Magnetic Phenomena
  • Magnetite Nanoparticles (chemistry)
  • Microspheres
  • Nanomedicine (methods)
  • Nanostructures (chemistry)
  • Oxidation-Reduction
  • Polymerization
  • Polymers (chemical synthesis, chemistry)
  • Polymethacrylic Acids (chemical synthesis, chemistry)
  • Silver (chemistry)
  • Surface Properties
  • Temperature

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