The use of topical tacrolimus 0.1% skin ointment for anterior segment conditions: a case series.

Abstract

Tacrolimus (FK 506) is a macrolactam derivative with immunomodulatory and anti-inflammatory activity. Topical tacrolimus 0.03% has been used for inflammatory conditions of the anterior segment. This article adds to the literature on the off-license application of tacrolimus ointment, by describing the safe and effective use of the higher strength of 0.1% topical tacrolimus skin ointment in four patients. To our knowledge this is the first report of topical tacrolimus 0.1% ointment applied to the conjunctival sac for the treatment of atopic keratoconjunctivitis, vernal keratoconjunctivitis and the post-operative management of trabeculectomy and graft rejection in steroid responders.

• Authors: Poorna Abeysiri, Nicholas R Johnston, Anthony C B Molteno
• Journal: Ophthalmology and eye diseases (Ophthalmol Eye Dis) Vol. 2 Pg. 5-8 ( 2010) ISSN: 1179-1721 [Print] United States
• PMID: 23861611 (Publication Type: Case Reports)