Abstract | BACKGROUND: CASE PRESENTATION: A 28-year-old man was referred to the Department of Endocrinology of the University Hospital of Pisa with suspected MTC with laterocervical lymph node metastasis, a single liver lesion (10 mm), several bone metastases, and bilateral pheochromocytomas. RET genetic testing revealed a germline Cys634Arg mutation. During the hospitalization, the carcinoembryonic antigen and Ca 19-9 levels increased while the calcitonin concentration remained stable; despite the apparent stability of the lesions, the condition of the patient worsened rapidly and resulted in death. CONCLUSIONS: High levels of serum Ca 19-9 could be considered a marker of the dedifferentiation of MTC and disease aggressiveness, but additional data on the association between Ca 19-9 and advanced MTC are required to confirm this hypothesis.
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Authors | Rossella Elisei, Loredana Lorusso, Cristina Romei, Valeria Bottici, Salvatore Mazzeo, Claudio Giani, Emilio Fiore, Liborio Torregrossa, Andrea Cacciato Insilla, Fulvio Basolo, Antonello Guerini, Alessandra Menghi, Alessandro Poletti, Luisa Cugudda, Paolo Vitti |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 9
Pg. 3550-4
(Sep 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 23861463
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- CA-19-9 Antigen
- Calcitonin
- Proto-Oncogene Proteins c-ret
- RET protein, human
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Topics |
- Adrenal Gland Neoplasms
(blood, genetics, pathology)
- Adult
- Biomarkers, Tumor
(blood)
- CA-19-9 Antigen
(blood)
- Calcitonin
(blood)
- Carcinoma, Medullary
(blood, genetics, pathology)
- Disease Progression
- Humans
- Male
- Neoplasms, Multiple Primary
(blood, genetics, pathology)
- Pheochromocytoma
(blood, genetics, pathology)
- Proto-Oncogene Proteins c-ret
(genetics)
- Thyroid Neoplasms
(blood, genetics, pathology)
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