Two-year results of treatment with methionyl human growth hormone in children with Turner syndrome. Dutch Growth Hormone Working Group.

Abstract

Methionyl growth hormone (somatrem) in a daily dosage of 4 IU/m2 body surface area was administered to 16 girls with Turner syndrome. Low dose ethinyl estradiol (0.1 microgram/kg body weight) was added in girls aged 13 years or more. Mean (SD) height velocity increased from 3.4 (0.9) to 7.2 (1.7) and 5.3 (1.3) cm/year in the first and second year, respectively. Bone age advanced 1.8 years over 2 years and predicted adult height was increased. Apart from the occurrence of anti-GH antibodies there were no side effects. In conclusion, somatrem is an efficacious and safe therapy for short stature in Turner syndrome over a period of 2 years. Longer follow-up is needed before conclusions about its effect on final height can be drawn.

• Authors: C Rongen-Westerlaken, M H Fokker, J M Wit, S M De Muinck Keizer-Schrama, B J Otten, W Oostdijk, H A Delemarre van den waal, M H Gons, A Bot
• Journal: Acta paediatrica Scandinavica (Acta Paediatr Scand) 1990 Jun-Jul Vol. 79 Issue 6-7 Pg. 658-63 ISSN: 0001-656X [Print] Sweden
• PMID: 2386058 (Publication Type: Journal Article)

Chemical References

• Hormones
• Recombinant Proteins
• Human Growth Hormone
• Growth Hormone

Topics

• Adolescent
• Body Height (drug effects)
• Child
• Female
• Follow-Up Studies
• Growth Hormone (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Hormones (administration & dosage, adverse effects, therapeutic use)
• Human Growth Hormone
• Humans
• Recombinant Proteins (administration & dosage, adverse effects, therapeutic use)
• Turner Syndrome (drug therapy, physiopathology)