Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

Abstract

Our group recently reported the strong anti-inflammatory effects of geniposide (Gen), a bioactive iridoid glucoside derived from gardenia jasminoides, in a mouse acute lung injury model. Herein, we hypothesized that Gen might also have potential therapeutic benefits in treatment of asthma, which was tested in a mouse model of ovalbumin (Ova)-induced allergic airway inflammation. Ova-sensitized and -challenged BALB/c mice, as compared with control animals, displayed airway hyperresponsiveness (AHR), bronchoalveolar lavage eosinophilia, mucus hypersecretion, and increased T help 2 (Th2)-associated cytokine and chemokine amounts, as well as serum Ova-specific immunoglobulin E (IgE) level. Being compared with the Ova-induced hallmarks of asthma, intraperitoneal Gen treatment prevented eosinophilic pulmonary infiltration, attenuated the increases in interleukin (IL)-4, IL-5, and IL-13, and reduced eotaxin and vascular cell adhesion molecule 1 (VCAM-1) expression. Also, Gen significantly ameliorated the Ova-driven airway hyperresponsiveness, mucus hypersecretion, and allergen-specific IgE level, which are the cardinal pathophysiological symptoms in allergic airway diseases. In addition, the efficacy of Gen was comparable to that of dexamethasone (Dex), a currently available anti-asthmatic drug. Collectively, our findings reveal that the development of immunoregulatory strategies based on Gen may be considered as an effective adjuvant therapy for allergic asthma.

• Authors: Yanhong Deng, Mingfeng Guan, Xingxing Xie, Xiaofeng Yang, Hua Xiang, Hongyu Li, Lianchun Zou, Jingyuan Wei, Dacheng Wang, Xuming Deng
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 17 Issue 3 Pg. 561-7 (Nov 2013) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 23859870 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013. Published by Elsevier B.V. All rights reserved.

Chemical References

• Allergens
• Anti-Asthmatic Agents
• Anti-Inflammatory Agents
• Cytokines
• Iridoids
• geniposide
• Immunoglobulin E
• Ovalbumin

Topics

• Allergens (immunology)
• Animals
• Anti-Asthmatic Agents (pharmacology, therapeutic use)
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Asthma (drug therapy, immunology, pathology)
• Bronchial Hyperreactivity (drug therapy, immunology, pathology)
• Bronchoalveolar Lavage Fluid (cytology, immunology)
• Cell Count
• Cytokines (immunology)
• Disease Models, Animal
• Female
• Immunoglobulin E (blood)
• Iridoids (pharmacology, therapeutic use)
• Lung (drug effects, pathology)
• Mice
• Mice, Inbred BALB C
• Ovalbumin (immunology)