Abstract | BACKGROUND: AIM: METHODS: RESULTS:
Angiopoietin-1 acts as a regulator of blood vessel maturation and has anti-inflammatory properties, whereas angiopoietin-2 marks the onset of angiogenesis and is required for normal formation of lymph vessels. Both angiopoietins make use of their angiogenic regulatory effects via the angiopoietin tyrosine-kinase receptor (Tie-2). While angiogenesis has been shown to promote and sustain many events of inflammation, the involvement of the angiopoietin system in IBD has been reported in few studies. It is not clear whether the angiopoietins' role in the development of intestinal inflammation is due to an imbalance in the levels of these proteins or this system exerts its pro-angiogenic properties through a different mechanism during the close-loop relationship between angiogenesis and inflammation. CONCLUSIONS:
Angiopoietins have key functions in the angiogenic process, and their abnormal activation might depend on their surrounding inflamed environment. The determination of these angiogenic factors in serum and tissue could be useful for monitoring IBD progression.
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Authors | Pablo M Linares, María Chaparro, Javier P Gisbert |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 8
Issue 3
Pg. 183-90
(Mar 2014)
ISSN: 1876-4479 [Electronic] England |
PMID | 23859759
(Publication Type: Journal Article, Review)
|
Copyright | © 2013. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Angiopoietin-1
- Angiopoietin-2
- Receptor, TIE-2
|
Topics |
- Angiopoietin-1
(blood)
- Angiopoietin-2
(blood)
- Animals
- Humans
- Inflammation
(blood)
- Inflammatory Bowel Diseases
(blood, etiology)
- Receptor, TIE-2
(blood)
|