[Clinical analyses of perinuclear antineutrophil cytoplasmic antibody associated hypertrophic pachymeningitis].

Abstract

OBJECTIVE:

To explore the clinical characteristics, diagnosis, treatment and prognosis of perinuclear antineutrophil cytoplasmic antibody (p-ANCA) associated hypertrophic pachymeningitis.

METHODS:

A retrospective study was performed for 6 inpatients with p-ANCA associated hypertrophic pachymeningitis at our hospital from 2005 to 2012.

RESULTS:

There were 3 males and 3 females with an age range of 52 - 68 years. The main clinical manifestations included headache and multiple cranial neuropathies. Erythrocyte sedimentation rate, C-reactive protein, titer of myeloperoxidase (MPO)-ANCA and protein in cerebrospinal fluid were uniformly elevated in all 6 patients during active phase while cytoplasmic(c)-ANCA was all negative. Head magnetic resonance imaging (MRI) enhancement scan had a high diagnostic sensitivity. Different parts of dura were all thickened and obviously enhanced. Glucocorticoid was uniformly effective. During the follow-up period, 2 cases relapsed and received immunosuppressive agents.

CONCLUSION:

The disease should be considered in elderly patients with headache, cranial nerve injury and positive p-ANCA. And head MRI enhancement scan is helpful for diagnosis.

• Authors: Peng Zhao, Ben-shu Zhang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 93 Issue 11 Pg. 837-40 (Mar 19 2013) ISSN: 0376-2491 [Print] China
• PMID: 23859390 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic

Topics

• Aged
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Female
• Humans
• Hypertrophy
• Male
• Meningitis (blood, diagnosis)
• Middle Aged
• Retrospective Studies