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Maternal dietary canola oil suppresses growth of mammary carcinogenesis in female rat offspring.

Abstract
As suggested by rodent studies and studies using human breast cancer cells, dietary canola oil is linked with lower breast cancer risk. Here, we investigated the effect of maternal (pregnancy plus lactation) dietary canola oil on the susceptibility of female Sprague-Dawley rat offspring to mammary carcinogenesis. Although the control diet had 10% soybean oil, the treatment diet was formulated to contain 10% canola oil as a fat source. N-nitroso-N-methylurea was injected to induce mammary cancer in offspring. The offspring of canola-fed dams showed significantly decreased tumor multiplicity (1.0 ± 0.3 vs. 1.9 ± 0.3, respectively; P = 0.04) and tumor volume (1232.5 ± 771.0 mm(3) vs. 6,302.5 ± 1,747.4 mm(3), respectively; P = 0.01), along with increased survival rate (87% vs. 47%, respectively; P = 0.01). In addition, the mRNA expression of development-related gamma-glutamyltransferase 1 was significantly higher in the lactating mammary tissues of the canola group dams and mammary tumor tissues of the offspring [2.5 ± 0.6 vs. 0.5 ± 0.2, respectively (P = 0.01) and 0.98 ± 0.03 vs. 0.56 ± 0.15, respectively (P = 0.05)]. These results suggest a potential anticancer effect of maternal dietary canola oil and may be useful in devising prenatal nutritional strategies to reduce breast cancer risk in humans.
AuthorsLawrence Mabasa, Kyongshin Cho, Mark W Walters, Sajin Bae, Chung S Park
JournalNutrition and cancer (Nutr Cancer) Vol. 65 Issue 5 Pg. 695-701 ( 2013) ISSN: 1532-7914 [Electronic] United States
PMID23859037 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Dietary Fats
  • Fatty Acids, Monounsaturated
  • Rapeseed Oil
  • Methylnitrosourea
Topics
  • Animals
  • Body Weight
  • Carcinogenesis
  • Diet
  • Dietary Fats (administration & dosage)
  • Disease Models, Animal
  • Fatty Acids, Monounsaturated (administration & dosage)
  • Female
  • Lactation
  • Mammary Neoplasms, Experimental (chemically induced, prevention & control)
  • Maternal Nutritional Physiological Phenomena
  • Methylnitrosourea (toxicity)
  • Pregnancy
  • Rapeseed Oil
  • Rats
  • Rats, Sprague-Dawley

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