Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS:
Mebudipine significantly reduced the MDA level (2.3 ± 0.07 nmol/mg protein) as the biochemical indicator of oxidative damage and lipid peroxidation product as compared with those of vehicle (4.6 ± 0.01 nmol/mg protein) and control groups (4.8 ± 0.09 nmol/mg protein). Furthermore, antioxidant enzymes SOD (0.1 ± 0.006 in drug vs. 0.037 ± 0.009 U/mg Protein in control), GPX (16 ± 0.009 in drug vs. 0.068 ± 0.01 U/mg Protein in control) and catalase activities (0.075 ± 0.006 in drug vs. 0.028 ± 0.002 U/mg Protein in control), activities of myocardium were significantly increased by mebudipine (P < 0.01). CONCLUSION:
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Authors | Rafigheh Ghyasi, Gholamreza Sepehri, Mustafa Mohammadi, Reza Badalzadeh, Akbar Ghyasi |
Journal | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
(J Res Med Sci)
Vol. 17
Issue 12
Pg. 1150-5
(Dec 2012)
ISSN: 1735-1995 [Print] India |
PMID | 23853633
(Publication Type: Journal Article)
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