HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Serum brain-derived neurotrophic factor levels are associated with dyssomnia in females, but not males, among Japanese workers.

AbstractSTUDY OBJECTIVES:
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that promote the growth and survival of neurons. Recent evidence suggests that BDNF is a sleep regulatory substance that contributes to sleep behavior. However, no studies have examined the association between the serum BDNF levels and dyssomnia. The present study was conducted to clarify the association between the serum BDNF levels and dyssomnia.
METHODS:
A total of 344 workers (age: 40.1 ± 10.5 years, male: 204, female: 140) were included in the study. The serum BDNF levels were categorized into tertiles according to sex.
RESULTS:
The prevalence of dyssomnia was 35.1% in males and 30.0% in females. In the females, the BDNF levels were found to be negatively associated with dyssomnia after adjusting for age, body mass index, hypertension, dyslipidemia, hyperglycemia, depression, smoking, alcohol intake, and regular exercise. Compared with the females in the high BDNF group, the multivariate odds ratio (95% CI) of dyssomnia was 2.08 (0.62-6.98) in females in the moderate BDNF group and 8.41 (2.05-27.14) in females in the low BDNF group. No such relationships were found in the males.
CONCLUSIONS:
The serum BDNF levels are associated with dyssomnia in Japanese female, but not male, workers.
AuthorsReiko Nishichi, Yu Nufuji, Masakazu Washio, Shuzo Kumagai
JournalJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine (J Clin Sleep Med) Vol. 9 Issue 7 Pg. 649-54 (Jul 15 2013) ISSN: 1550-9397 [Electronic] United States
PMID23853557 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Brain-Derived Neurotrophic Factor
Topics
  • Adult
  • Brain-Derived Neurotrophic Factor (blood)
  • Dyssomnias (blood)
  • Employment
  • Female
  • Humans
  • Japan
  • Male
  • Odds Ratio
  • Sex Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: