NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis.

Abstract

No clear consensus has been reached on the

NAD(P)H:

quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer risk. We performed a meta-analysis to summarize the possible association. We conducted a computer retrieval of PubMed and Embase databases prior to May 2013. References of retrieved articles were also screened. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. According to the inclusion criteria, 25 articles (32 studies) were finally included. There was no statistical association between C609T polymorphism and lung cancer risk in overall, East Asians, African Americans, or Hispanics. In Caucasians, a significant association was found in allele comparison model (T vs. C) (P = 0.04, OR = 1.09, 95% CI 1.00-1.19, P(heterogeneity) = 0.24, fixed-effects model). In the subgroup of squamous cell carcinoma, a borderline significance could be found in the dominant genetic model (TT + CT vs. CC) (P = 0.05, OR = 1.20, 95% CI 1.00-1.43, P(heterogeneity) = 0.65, fixed-effects model). Significant association could also be found in allele comparison (T vs. C) (P = 0.03, OR = 1.21, 95% CI 1.01-1.44, P(heterogeneity) = 0.68, fixed-effects model). In the subgroup of small cell lung cancer risk, significant association were found in allele comparison (T vs. C) (P = 0.03, OR = 1.68, 95%CI 1.05-2.68, P(heterogeneity) = 0.10, random-effects model) and in the homozygote comparison (TT vs. CC) (P = 0.02, OR = 2.79, 95% CI 1.14-6.85, P heterogeneity = 0.72, fixed-effects model). No association was observed in adenocarcinoma subgroup. Our study suggested that NQO1 C609T polymorphism might associate with lung cancer risk in Caucasians. This polymorphism might also associate with squamous cell carcinoma and small cell lung cancer risk.

• Authors: Yuqing Lou, Rong Li, Liwen Xiong, Aiqin Gu, Chunlei Shi, Tianqing Chu, Xueyan Zhang, Ping Gu, Hua Zhong, Shaojun Wen, Baohui Han
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 34 Issue 6 Pg. 3967-79 (Dec 2013) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 23852860 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• NAD(P)H Dehydrogenase (Quinone)
• NQO1 protein, human

Topics

• Adenocarcinoma (ethnology, genetics)
• Black or African American (genetics)
• Asian People (genetics)
• Carcinoma, Squamous Cell (ethnology, genetics)
• Case-Control Studies
• Gene Frequency
• Genetic Predisposition to Disease (ethnology, genetics)
• Genotype
• Hispanic or Latino (genetics)
• Humans
• Lung Neoplasms (ethnology, genetics)
• NAD(P)H Dehydrogenase (Quinone) (genetics)
• Polymorphism, Single Nucleotide
• Publication Bias
• Risk Assessment (statistics & numerical data)
• Risk Factors
• Small Cell Lung Carcinoma (ethnology, genetics)
• White People (genetics)