Prevalence of hepatitis C virus infection and genotypes in patient with chronic kidney disease undergoing hemodialysis.

Abstract

The prevalence of antibodies to HCV varies among Brazilian regions at rates of 8-16%. Since this virus is transmitted by the parenteral route through blood and blood products, patients receiving maintenance hemodialysis therapy are at an increased risk of infection. The study was conducted in seven dialysis centers in Belém, Pará, northern Brazil. Blood samples were collected from 798 patients with chronic renal disease treated by hemodialysis. The samples were tested for antibodies against HCV and the viral genotype was identified. Sixty-seven (8.4%) of the 798 patients studied were anti-HCV positive by ELISA, ranging from 4% to 14% in different centers. Viral RNA was detected in 5.3% (43/798) of the patients; of these, 42 also had anti-HCV antibodies. HCV genotyping revealed genotype 1 as the most common, detected in 86.1% (37/43) of the patients, followed by genotype 2 in 11.6% (5/43) and genotype 3 in one patient (2.3%). The findings of this study highlight the importance of control strategies for hepatitis C in hemodialysis patients. Molecular biology methods need to be available in these centers to screen for HCV on admission in order to establish effective infection control measures.

• Authors: Maria de Jesus Rodrigues de Freitas, Amanda Alves Fecury, Marcella Kelly Costa de Almeida, Andrei Silva Freitas, Vanessa de Souza Guimarães, Andrea Marinho da Silva, Ygor Fernando Ferreira da Costa, Renata Aparecida Andrade da Costa, Patrícia Ferreira, Luisa Caricio Martins
• Journal: Journal of medical virology (J Med Virol) Vol. 85 Issue 10 Pg. 1741-5 (Oct 2013) ISSN: 1096-9071 [Electronic] United States
• PMID: 23852735 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Chemical References

• Hepatitis C Antibodies
• RNA, Viral

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Brazil (epidemiology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Genotype
• Hepacivirus (classification, genetics, isolation & purification)
• Hepatitis C (epidemiology)
• Hepatitis C Antibodies (blood)
• Humans
• Male
• Middle Aged
• Prevalence
• RNA, Viral (blood, genetics)
• Renal Dialysis (adverse effects)
• Renal Insufficiency, Chronic (complications)
• Young Adult