The effects of zoledronic acid on mandibular fracture healing in an osteoporotic model: a stereological study.

Abstract

The aim of this study was to evaluate the effect of zoledronic acid (ZA) in the ovariectomized rat on mandibular fracture. Corpus osteotomies were performed on the mandible of ovariectomized rats. Miniplates were placed on these rats, which were randomly divided into 4 groups. After 7 days, groups 3 and 4 were injected with 0.1 mg/kg ZA. Groups 1 and 2 were control groups, so they were injected 0.1 mg/kg saline solution. Animals in groups 1 and 3 were killed at 4 weeks, whereas groups 2 and 4 were killed 8 weeks after operation. The new bone volume of the fracture gap was examined stereologically. Although the difference was not statistically significant compared with the other groups (groups 1 and 3), more bone formation was found in ZA-treated groups (groups 2 and 4) (P < 0.05).

• Authors: Ismail Sener, Cihan Bereket, Huseyin Kosker, Akif Turer, Mustafa Tek, Suleyman Kaplan
• Journal: The Journal of craniofacial surgery (J Craniofac Surg) Vol. 24 Issue 4 Pg. 1221-4 (Jul 2013) ISSN: 1536-3732 [Electronic] United States
• PMID: 23851773 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bone Density Conservation Agents
• Diphosphonates
• Imidazoles
• Zoledronic Acid

Topics

• Animals
• Bone Density Conservation Agents (therapeutic use)
• Bone Plates
• Diphosphonates (therapeutic use)
• Disease Models, Animal
• Female
• Fracture Healing (drug effects, physiology)
• Imidazoles (therapeutic use)
• Mandible (drug effects)
• Mandibular Fractures (drug therapy, pathology)
• Osteogenesis (drug effects)
• Osteoporosis (complications, physiopathology)
• Ovariectomy
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Time Factors
• Zoledronic Acid