Adenosquamous carcinoma of the head and neck: report of 20 cases and review of the literature.

Abstract

PURPOSE:

To assess the clinical profile and prognostic factors in patients with adenosquamous carcinoma (ASC) of the head and neck treated by surgery and/or radiation therapy with or without chemotherapy.

METHODS:

Data from 20 patients with stage I-II (n = 4), III (n = 5), or IVA (n = 11) head and neck ASC, treated between 1989 and 2010 were collected in a retrospective multicenter Rare Cancer Network study. Surgery was performed in 16 patients. Seventeen patients received combined modality treatment.

RESULTS:

After a median follow-up of 15.5 months, 12 patients recurred. The 3-year and median overall survival, disease-free survival (DFS), and loco-regional control were 52% and 39 months, 32% and 12 months, and 47% and 33 months respectively. In multivariate analysis, DFS was negatively influenced by the presence of extracapsular extension and advanced stage.

CONCLUSION:

Overall prognosis of locoregionally advanced ASC remains poor. However, early stage ASC patients managed with combined modality treatment may have prolonged DFS.

• Authors: Ulrike Schick, Marc Pusztaszeri, Michael Betz, Pirus Ghadjar, Candan Demiroz, Johannes H A M Kaanders, Mahmut Ozsahin
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 116 Issue 3 Pg. 313-20 (Sep 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 23850369 (Publication Type: Journal Article, Multicenter Study, Review)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Adenosquamous (mortality, pathology, therapy)
• Disease-Free Survival
• Female
• Head and Neck Neoplasms (mortality, pathology, therapy)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoplasm Recurrence, Local (mortality, pathology, therapy)
• Netherlands (epidemiology)
• Prognosis
• Proportional Hazards Models
• Rare Diseases (epidemiology)
• Retrospective Studies
• Survival Rate
• Switzerland (epidemiology)
• Turkey (epidemiology)