Casbane diterpenoids from the roots of Euphorbia pekinensis.

Abstract

Four casbane diterpenoids, together with three known related compounds were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. In addition, the absolute configuration of three compounds was determined by the modified Mosher's method. The isolated compounds were evaluated for their cytotoxic activity against seven human cancer cell lines by a WST-8 assay.

• Authors: Wei-Wei Tao, Jin-Ao Duan, Yu-Ping Tang, Nian-Yun Yang, Jian-Ping Li, Ye-Fei Qian
• Journal: Phytochemistry (Phytochemistry) Vol. 94 Pg. 249-53 (Oct 2013) ISSN: 1873-3700 [Electronic] England
• PMID: 23849544 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Euphorbia (chemistry)
• HL-60 Cells
• Humans
• Inhibitory Concentration 50
• MCF-7 Cells
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Plant Roots (chemistry)