Abstract | OBJECTIVE: This study aimed to determine if screening for preeclampsia could be improved between 20 and 24 weeks of gestation by uterine artery Doppler (UAD), biomarkers and lipid-related markers. METHOD: RESULTS: The study at Tours University Hospital took place from March 2003 to February 2008 and included 235 women: 56 (23.8%) developed preeclampsia, 42 were severe (17.8%) and 14 occurred before 34 weeks of gestation (5.9%). The group with preeclampsia had a higher UAD pulsatility index (p = 0.0003), more frequent bilateral notches (p = .0001), lower PlGF levels (239.90 vs 302.00 pg/mL; p = 0.0015), and higher triglyceride (1.95 vs 1.70 mmol/l; p = 0.0068) and leptin levels (37.40 vs 22.55 ng/mL; p = < 0.001). No significant differences were observed for other markers. Screening for preeclampsia using these Doppler and laboratory findings produced an area under the curve of 0.795. CONCLUSION:
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Authors | Caroline Diguisto, Amélie Le Gouge, Eric Piver, Bruno Giraudeau, Franck Perrotin |
Journal | Prenatal diagnosis
(Prenat Diagn)
Vol. 33
Issue 11
Pg. 1070-4
(Nov 2013)
ISSN: 1097-0223 [Electronic] England |
PMID | 23847040
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons, Ltd. |
Chemical References |
- Antigens, CD
- Biomarkers
- ENG protein, human
- Endoglin
- Lipids
- PGF protein, human
- Pregnancy Proteins
- Receptors, Cell Surface
- Placenta Growth Factor
- FLT1 protein, human
- Vascular Endothelial Growth Factor Receptor-1
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Topics |
- Adult
- Antigens, CD
(blood)
- Biomarkers
(blood)
- Endoglin
- Female
- Humans
- Lipid Metabolism
- Lipids
(blood)
- Maternal Serum Screening Tests
- Placenta Growth Factor
- Pre-Eclampsia
(blood, diagnostic imaging, epidemiology)
- Pregnancy
- Pregnancy Outcome
(epidemiology)
- Pregnancy Proteins
(blood)
- Pregnancy Trimester, Second
(blood)
- Prognosis
- Receptors, Cell Surface
(blood)
- Risk Factors
- Ultrasonography, Doppler
- Ultrasonography, Prenatal
- Uterine Artery
(diagnostic imaging)
- Vascular Endothelial Growth Factor Receptor-1
(blood)
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