Topical Mitomycin C application for esophageal stricture: safe, precise, and novel endoscopic technique.

Abstract

PURPOSE:

The first line of management of benign esophageal stricture is endoscopic dilatation; however, multiple sessions are usually indicated especially in resistant cases. Topical Mitomycin C (MCC) application is a new adjuvant treatment in the management of esophageal stricture with promising results in different case series. Several techniques have been reported for application; nevertheless, the ideal technique has not been described yet.

MATERIAL AND METHODS:

In this series we have devised a new technique using both the flexible and the rigid endoscope and a specially designed Nelaton catheter.

RESULTS:

This technique was applied in 38 sessions for 16 caustic esophageal strictures with technical success in all cases. No procedure-related complications were observed in this series.

CONCLUSION:

This novel technique is feasible and effective and can be considered as standard for topical MMC application on esophageal stricture.

• Authors: Khaled Mohamed El-Asmar
• Journal: Journal of pediatric surgery (J Pediatr Surg) Vol. 48 Issue 6 Pg. 1454-7 (Jun 2013) ISSN: 1531-5037 [Electronic] United States
• PMID: 23845649 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Alkylating Agents
• Mitomycin

Topics

• Administration, Topical
• Alkylating Agents (therapeutic use)
• Burns, Chemical (complications, drug therapy, therapy)
• Catheters
• Child
• Combined Modality Therapy
• Dilatation (instrumentation, methods)
• Esophageal Stenosis (chemically induced, drug therapy, therapy)
• Esophagoscopes
• Esophagoscopy (instrumentation, methods)
• Follow-Up Studies
• Humans
• Mitomycin (therapeutic use)
• Treatment Outcome