Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility: a meta-analysis.

Abstract

OBJECTIVE:

The aim of this study was to determine whether interleukin (IL)-23 R and IL-12B polymorphisms confer susceptibility to psoriasis.

METHODS:

The authors conducted a meta-analysis on associations between the IL-23 R and IL-12B polymorphisms and psoriasis susceptibility.

RESULTS:

A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR] = 0.624, 95% confidence interval [CI] = 0.565-0.697, p < 1.0 × 10(-8); OR = 0.804, 95% CI = 0.743-0.869, p = 3.0 × 10(-7), respectively). Meta-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR = 0.710, 95% CI = 0.673-0.749, p < 1.0 × 10(-8); OR = 0.684, 95% CI = 0.639-0.731, p < 1.0 × 10(-8), respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans.

CONCLUSIONS:

This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.

• Authors: Young Ho Lee, Gwan Gyu Song
• Journal: Immunological investigations (Immunol Invest) Vol. 42 Issue 8 Pg. 726-36 ( 2013) ISSN: 1532-4311 [Electronic] England
• PMID: 23844553 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• IL12B protein, human
• IL23R protein, human
• Interleukin-12 Subunit p40
• Receptors, Interleukin

Topics

• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Interleukin-12 Subunit p40 (genetics)
• Polymorphism, Genetic
• Psoriasis (genetics)
• Receptors, Interleukin (genetics)
• Risk
• White People