Abstract | OBJECTIVE: The aim of this study was to determine whether interleukin (IL)-23 R and IL-12B polymorphisms confer susceptibility to psoriasis. METHODS: The authors conducted a meta-analysis on associations between the IL-23 R and IL-12B polymorphisms and psoriasis susceptibility. RESULTS: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR] = 0.624, 95% confidence interval [CI] = 0.565-0.697, p < 1.0 × 10(-8); OR = 0.804, 95% CI = 0.743-0.869, p = 3.0 × 10(-7), respectively). Meta-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR = 0.710, 95% CI = 0.673-0.749, p < 1.0 × 10(-8); OR = 0.684, 95% CI = 0.639-0.731, p < 1.0 × 10(-8), respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. CONCLUSIONS: This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.
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Authors | Young Ho Lee, Gwan Gyu Song |
Journal | Immunological investigations
(Immunol Invest)
Vol. 42
Issue 8
Pg. 726-36
( 2013)
ISSN: 1532-4311 [Electronic] England |
PMID | 23844553
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- IL12B protein, human
- IL23R protein, human
- Interleukin-12 Subunit p40
- Receptors, Interleukin
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Topics |
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Interleukin-12 Subunit p40
(genetics)
- Polymorphism, Genetic
- Psoriasis
(genetics)
- Receptors, Interleukin
(genetics)
- Risk
- White People
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