The use of biatain Ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials.

Abstract

BACKGROUND:

Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs).

AIM:

To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing.

PATIENTS AND METHODS:

685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis.

RESULTS:

Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002).

CONCLUSION:

The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.

• Authors: David Leaper, Christian Münter, Sylvie Meaume, Alessandro Scalise, Nacho Blanes Mompó, Birte Petersen Jakobsen, Finn Gottrup
• Journal: PloS one (PLoS One) Vol. 8 Issue 7 Pg. e67083 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23843984 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Polyurethanes
• Silver Compounds
• polyurethane foam

Topics

• Aged
• Aged, 80 and over
• Anti-Infective Agents, Local (pharmacology)
• Bandages
• Female
• Humans
• Male
• Middle Aged
• Polyurethanes (chemistry)
• Randomized Controlled Trials as Topic
• Silver Compounds (pharmacology)
• Treatment Outcome
• Varicose Ulcer (drug therapy)
• Wound Healing (drug effects)