Abstract |
Superficial siderosis is caused by recurrent haemorrhage in the subarachnoid space leading to haemosiderin deposition. It typically causes the triad of ataxia, deafness and myelopathy. We report a patient who developed superficial siderosis following neurosurgery for syringomyelia and who had an improvement in his hearing and mobility following treatment with a new iron chelation therapy that can penetrate the blood-brain barrier. It provides an intriguing insight into a therapy that could potentially modify the course of this rare neurodegenerative disorder. Further studies are required to assess the clinical efficacy of deferiprone in superficial siderosis.
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Authors | Gemma Cummins, Gemma Crundwell, David Baguley, Graham Lennox |
Journal | BMJ case reports
(BMJ Case Rep)
Vol. 2013
(Jul 09 2013)
ISSN: 1757-790X [Electronic] England |
PMID | 23843408
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Iron Chelating Agents
- Pyridones
- Deferiprone
- Iron
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Topics |
- Aged
- Chelation Therapy
- Deferiprone
- Humans
- Iron
- Iron Chelating Agents
(therapeutic use)
- Male
- Pyridones
(therapeutic use)
- Siderosis
(drug therapy)
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