Osteogenic sarcoma and myasthenia gravis in a dog.

A 7-year-old Saint Bernard developed muscular weakness 1 year after right forelimb amputation and adjuvant cisplatin chemotherapy for osteogenic sarcoma. Clinical and laboratory findings supported a diagnosis of myasthenia gravis, and the dog had clinical improvement in response to prednisone treatment. Two additional dogs with myasthenia gravis and osteogenic sarcoma were identified by review of the medical records of the University of California Veterinary Medical Teaching Hospital. Findings indicated that myasthenia gravis or other neuromuscular transmission disorders may be associated with muscular weakness in dogs with osteogenic sarcoma.
AuthorsA S Moore, B R Madewell, G H Cardinet 3rd, G D Shelton
JournalJournal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 197 Issue 2 Pg. 226-7 (Jul 15 1990) ISSN: 0003-1488 [Print] UNITED STATES
PMID2384323 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cisplatin
  • Animals
  • Bone Neoplasms (complications, drug therapy, veterinary)
  • Cisplatin (adverse effects, therapeutic use)
  • Dog Diseases
  • Dogs
  • Forelimb
  • Male
  • Myasthenia Gravis (chemically induced, complications, veterinary)
  • Osteosarcoma (complications, drug therapy, veterinary)

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