Purpose. Contrast-induced nephropathy (CIN) can contribute to
acute kidney injury (AKI) in patients undergoing endovascular
aortic aneurysm surgery. We evaluated the incidence of AKI together with the evolution of early
biomarkers of renal injury in patients receiving
bicarbonates or NaCl 0.9%. Methods. This study involved endovascular
aortic aneurysm surgery patients. Group A (n = 17) received
bicarbonates 3 mL/kg/h for 1 h before the procedure and then 1 mL/kg/h until 6 h after surgery, whereas group B (n = 17) received NaCl 0.9% using the same protocol.
Biomarkers of renal injury from urine (
interleukin-18 (IL-18),
neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-
glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1)) and blood (NGAL,
cystatin C) were measured at baseline and 3, 24, and 48 h postoperatively. Results. AKI occurred in 1 patient (2.9%), in the
bicarbonates group.
IL-18, NAG, NGAL, and KIM-1 significantly rose in both groups after the surgery. There was a greater rise in NGAL and
IL-18 after 3 h in the
bicarbonates versus NaCl 0.9% group: 1115% versus 240% increase (P = 0.03) and 338% increase versus 1.4% decrease (P = 0.01). Conclusions. Despite significant elevation in
biomarkers of renal injury, we demonstrated a low rate of AKI following endovascular aortic surgery.