Abstract | BACKGROUND: METHODS: RESULTS: ICI 174,864 (0.1-3 mg/kg) with or without 1/4 volume of LR infusion showed dose-dependent increase in the mean arterial blood pressure, and significantly prolonged the survival time and 8-h survival rate, as compared with ICI 174,864 plus 1/2 volume of LR infusion. The best effect was shown with 3 mg/kg of ICI 174,864. Bleeding cessation at 1, 2, or 3 h during infusion of ICI 174,864 (3 mg/kg) plus 1/4 volume of LR improved subsequent treatment (70% 24-h survival rate vs. 50 and 10% 24-h survival rate in hypotensive resuscitation and LR group, respectively). There was significant improvement in hemodynamic parameters, oxygen delivery, and tissue perfusion of hemorrhagic-shock rats with 3 mg/kg of ICI 174,864 plus 1/4 volume of LR infusion. CONCLUSION:
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Authors | Liangming Liu, Kunlun Tian, Yu Zhu, Xiaoli Ding, Tao Li |
Journal | Anesthesiology
(Anesthesiology)
Vol. 119
Issue 2
Pg. 379-88
(Aug 2013)
ISSN: 1528-1175 [Electronic] United States |
PMID | 23838715
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Narcotic Antagonists
- Receptors, Opioid, delta
- Enkephalin, Leucine
- N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enkephalin, Leucine
(analogs & derivatives, therapeutic use)
- Narcotic Antagonists
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Receptors, Opioid, delta
(antagonists & inhibitors)
- Shock, Hemorrhagic
(drug therapy)
- Survival Analysis
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