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A new treatment for polycythemia vera: recombinant interferon alfa.

Abstract
Recombinant interferon alfa, a natural product with growth inhibitory capabilities, has been demonstrated for the first time to have significant therapeutic efficacy in controlling the red cell mass in patients with the myeloproliferative disease polycythemia vera. The starting dose was 3.0 X 10(6) U three times a week, subcutaneously (SC). In three patients the dose required was 5.0 X 10(6), U five times a week, SC. Side effects were easily tolerated. The striking advantage in the use of this drug is its presumed absence of antileukemic effect. Further evaluation is necessary, but the initial responses are encouraging.
AuthorsR T Silver
JournalBlood (Blood) Vol. 76 Issue 4 Pg. 664-5 (Aug 15 1990) ISSN: 0006-4971 [Print] UNITED STATES
PMID2383649 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon Type I
  • Recombinant Proteins
Topics
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Informed Consent
  • Interferon Type I (adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Polycythemia Vera (drug therapy, epidemiology, pathology)
  • Recombinant Proteins

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