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EGFR gets in the way of microRNA biogenesis.

Abstract
Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.
AuthorsNaohiro Nishida, Koshi Mimori, Masaki Mori, George A Calin
JournalCell research (Cell Res) Vol. 23 Issue 10 Pg. 1157-8 (Oct 2013) ISSN: 1748-7838 [Electronic] England
PMID23835474 (Publication Type: Journal Article, Comment)
Chemical References
  • Argonaute Proteins
  • MicroRNAs
  • ErbB Receptors
Topics
  • Argonaute Proteins (chemistry, metabolism)
  • Cell Hypoxia (physiology)
  • ErbB Receptors (metabolism)
  • Female
  • Humans
  • MicroRNAs (metabolism)

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