Abstract | PURPOSE:
Stroke still remains a challenge for the researchers and scientists for developing ideal drug. Several new drugs are being evaluated showing excellent results in preclinical studies but when tested in clinical trials, they failed. Many herbal drugs in different indigenous system of medicine claim to have beneficial effects but not extensively evaluated for stroke (cerebral ischemia). AIM: The present study was undertaken to evaluate chloroform and petroleum ether extract of Nigella sativa seeds administered at a dose of 400 mg/kg, per orally for seven days in middle cerebral artery occluded (MCAO) rats for its neuroprotective role in cerebral ischemia. MATERIALS AND METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion for two hours followed by reperfusion for 22 hours. After 24 hours, grip strength, locomotor activity tests were performed in different treatment groups of rats. After completing behavioral tests, animals were sacrificed; brains were removed for the measurement of infarct volume followed by the estimation of markers of oxidative stress. RESULTS: CONCLUSION:
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Authors | Mohammad Akhtar, Aliyu Muhammad Maikiyo, Abul Kalam Najmi, Razia Khanam, Mohd Mujeeb, Mohd Aqil |
Journal | Journal of pharmacy & bioallied sciences
(J Pharm Bioallied Sci)
Vol. 5
Issue 2
Pg. 119-25
(Apr 2013)
ISSN: 0976-4879 [Print] India |
PMID | 23833517
(Publication Type: Journal Article)
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