Abstract |
Epigenetic silencing mechanisms play an important role in chemoresistance of human cancer. Here we report the upregulated expression of metastasis-associated protein 1 (MTA1), a component of the nucleosome remodeling deacetylation ( NuRD) complex, in chemoresistant prostate cancer (PCa). MTA1 knockdown in PC-3 cells inhibited cell proliferation and enhanced docetaxel (DTX)-induced cell death. Conversely, overexpression of MTA1 promotes DTX chemoresistance in PC-3 cells. MTA1 acted as a potent corepressor of the nuclear receptor NR4A1 transcription by interacting with histone deacetylase 2 (HDAC2). These findings suggest that MTA1 may serve as a novel DTX-resistance promoter in PC-3 cells.
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Authors | Liang Yu, Yan-sheng Su, Jie Zhao, He Wang, Wei Li |
Journal | FEBS letters
(FEBS Lett)
Vol. 587
Issue 16
Pg. 2542-51
(Aug 19 2013)
ISSN: 1873-3468 [Electronic] England |
PMID | 23831020
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Chromatin
- Mta1 protein, human
- NR4A1 protein, human
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Repressor Proteins
- Taxoids
- Trans-Activators
- Docetaxel
- Histone Deacetylase 2
- Histone Deacetylases
- Mi-2 Nucleosome Remodeling and Deacetylase Complex
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Topics |
- Animals
- Apoptosis
- Cell Death
- Cell Line, Tumor
- Cell Survival
- Chromatin
(chemistry)
- Docetaxel
- Drug Resistance, Neoplasm
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Histone Deacetylase 2
(metabolism)
- Histone Deacetylases
(metabolism)
- Humans
- Male
- Mi-2 Nucleosome Remodeling and Deacetylase Complex
(metabolism)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Nuclear Receptor Subfamily 4, Group A, Member 1
(metabolism)
- Prostatic Neoplasms
(metabolism)
- Protein Binding
- Repressor Proteins
(metabolism)
- Taxoids
(pharmacology)
- Trans-Activators
- Transcription, Genetic
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